As Tendências do trabalho do serviço social na saúde em relação aos fundamentos do SUS e do projeto ético-político da profissão

TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Serviço Social

Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition

A unique collection of oceanic samples was gathered by the Tara Oceans expeditions (2009-2013), targeting plankton organisms ranging from viruses to metazoans, and providing rich environmental context measurements. Thanks to recent advances in the field of genomics, extensive sequencing has been performed for a deep genomic analysis of this huge collection of samples. A strategy based on different approaches, such as metabarcoding, metagenomics, single-cell genomics and metatranscriptomics, has been chosen for analysis of size-fractionated plankton communities. Here, we provide detailed procedures applied for genomic data generation, from nucleic acids extraction to sequence production, and we describe registries of genomics datasets available at the European Nucleotide Archive (ENA, www.ebi.ac.uk/ena). The association of these metadata to the experimental procedures applied for their generation will help the scientific community to access these data and facilitate their analysis. This paper complements other efforts to provide a full description of experiments and open science resources generated from the Tara Oceans project, further extending their value for the study of the world's planktonic ecosystems

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Desempenho agronômico e forrageiro de linhagens S4 de milho em topcrosses com híbrido simples

The objective of this study was to evaluate the relative performance of 74 partially inbred lines (S4) from crosses between the commercial hybrids P30P70 and Dow8460 in topcrosses with the commercial single cross hybrid P30F53 (tester), and checks (hybrids Dow8460, P30F53 and Status). The grain yield (GY) was evaluated in two environments in Guarapuava-PR. The effects of genotypes, environments and genotypes x environments interaction were significant for grain yield (GY). Among the topcrosses hybrids (TCH) the GY ranged from 8,302 (TCH 123, in the environment 2) to 14,809 kg ha-1 (TCH 11, in the environment 1). In the environment 1 we evaluated agronomic characteristics of the forage and bromatologic characteristics of the silage. The green mass productivity (GMP) of forage ranged from 49,857 (TCH 208) to 80,642 kg ha-1 (TCH 22) and the dry mass productivity (DMP) ranged from 11,072 (TCH 217) to 24,143 kg ha-1 (TCH 22). The contents of neutral detergent fiber (NDF) ranged from 45.39 (TCH 80) to 56.71% (TCH 77) and the contents of acid detergent fiber (ADF) ranged from 25.45 (TCH 80) to 35 60% (TCH 99). The relative value of the silage (RVS) presented average ratios ranged from 103 (TCH 148) to 142 (TCH 80). For all the characteristics many topcrosses did not differ from the best checks. TCH 22 and 53 were higher considering the set of all characteristics of forage and silage and, also, it showed high grain yield, therefore, these inbred lines should be advanced in the breeding program. O objetivo do trabalho foi avaliar o comportamento relativo de 74 linhagens parcialmente endogâmicas (S4) provenientes do cruzamento entre os híbridos comerciais P30P70 e Dow8460 em topcrosses com o híbrido simples comercial P30F53 (testador), mais as testemunhas (híbridos Dow8460, P30F53 e Status). A produtividade de grãos (PG) foi avaliada em dois ambientes em Guarapuava-PR. Houve efeito significativo de genótipos, ambientes e da interação genótipos x ambientes quanto à produtividade de grãos (PG). Entre os híbridos topcrosses (HTC) a PG variou de 8.302 (HTC 123, no ambiente 2) a 14.809 kg ha-1 (HTC 11, no ambiente 1). No ambiente 1 foram avaliadas características agronômicas da forragem e bromatológicas da silagem. A produtividade de massa verde (PMV) da forragem variou de 49.857 (HTC 208) a 80.642 kg ha-1 (HTC 22) e a produtividade de massa seca (PMS) variou de 11.072 (HTC 217) a 24.143 kg ha-1 (HTC 22). Os teores de fibra em detergente neutro (FDN) variaram de 45,39 (HTC 80) a 56,71% (HTC 77) e os teores de fibra em detergente ácido (FDA) variaram de 25,45 (HTC 80) a 35,60% (HTC 99). Para o valor relativo da silagem (VRS) foram obtidos índices médios variando de 103 (HTC 148) à 142 (HTC 80). Para todos os caracteres houve topcrosses que não diferiram das melhores testemunhas. Os HTC 22 e 53 foram superiores considerando todo o conjunto de caracteres forrageiros e bromatológicos da silagem e, ainda, apresentaram elevada produtividade de grãos, portanto, as respectivas linhagens genitoras devem ser avançadas no programa de melhoramento

Novel Pharmacokinetics Profiler (PhaKinPro): Model Development, Validation, and Implementation as a Web-Tool for Triaging Compounds with Undesired PK Profiles

Computational models that predict PK properties, such as those related to drug absorption, metabolism, distribution, and excretion, are critical to flagging drug candidates with poor PK profiles that emerge as hits in high-throughput screening campaigns. To support the development of reliable computational models to predict key PK properties, we collected, curated, and integrated a database of compounds tested in 13 major PK endpoints containing over 10,000 unique molecules. We built classification quantitative structure-activity relationship (QSAR) models for all but one endpoint (Cmax) following best practices of model development and validation. Those with acceptable external accuracy (CCR ≥ 0.60 and SE, PPV, SP, and NPV ≥ 0.50) include hepatic stability at 15, 30, and 60 minutes, hepatic half-life at the subcellular and tissue levels, renal clearance, blood brain barrier permeability, CNS activity, Caco-2 permeability, plasma protein binding, plasma half-life, microsomal intrinsic clearance, and oral bioavailability. As a case study to illustrate model utility, we employed all developed models to predict the PK properties of all compounds in DrugBank. We also predicted PK properties of molecules hitting popular drug targets among several organs SLC6A4 (brain), ADRB2 (heart and lungs), HMGCR (liver), and CaSR (kidneys) only. These analyses revealed that nearly all experimental, investigational, and withdrawn compounds included in DrugBank are hepatically stable at 60 minutes and under, exhibit CNS activity, and permeate the Caco-2 cell line (a measure of intestinal absorption). Furthermore, our results indicate that compounds targeting different organs have distinct predicted PK profiles. This observation suggests that desired PK properties depend on compound’s indication. All models described in this paper have been integrated and made publicly available via the novel predictor of pharmacokinetic properties (PhaKinPro) web portal that can be accessed at https://phakinpro.mml.unc.edu/

Albert_et_al_2018_TNF_Gs_porometer

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Albert_et_al_2018_TNF_leaf_chlorophyll_data

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Albert_et_al_2018_TNF_gas_exchange_parameters

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Albert_et_al_2018_TNF_leaf_demo_data

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Data from: Age-dependent leaf function and consequences for crown-scale carbon uptake during the dry season in an Amazon evergreen forest

* Satellite and tower-based metrics of forest-scale photosynthesis generally increase with dry season progression across central Amazônia, but the underlying mechanisms lack consensus. * We conducted demographic surveys of leaf age composition, and measured age-dependence of leaf physiology in broadleaf canopy trees of abundant species at a central eastern Amazon site. Using a novel leaf-to-branch scaling approach, we used this data to independently test the much-debated hypothesis—arising from satellite and tower-based observations—that leaf phenology could explain the forest-scale pattern of dry season photosynthesis. * Stomatal conductance and biochemical parameters of photosynthesis were higher for recently mature leaves than for old leaves. Most branches had multiple leaf age categories simultaneously present, and the number of recently mature leaves increased as the dry season progressed because old leaves were exchanged for new leaves. * These findings provide the first direct field evidence that branch-scale photosynthetic capacity increases during the dry season, with a magnitude consistent with increases in ecosystem-scale photosynthetic capacity derived from flux towers. Interaction between leaf age-dependent physiology and shifting leaf age-demographic composition are sufficient to explain the dry season photosynthetic capacity pattern at this site, and should be considered in vegetation models of tropical evergreen forests